This work, however, is at least more accessible to Americans; being a sexually charged thriller, its themes travel better over the waves of language that separate us. “The Skin I Live In” is scheduled to open soon at AMC Quail Springs Mall 24.

No stranger to Almodóvar’s sandbox, ol’ “Puss in Boots” himself, Antonio Banderas, portrays Dr. Robert Ledgard, one of the world’s leading plastic surgeons, having performed three of the globe’s nine face transplants. Behind the walls of his home, he’s conducting an experiment to be filed squarely under the category of Weird Science: creating artificial skin so impervious, it’s better than the real deal.

He already has a guinea pig, in Vera (Elena Anaya, “Van Helsing”), a strikingly beautiful woman who wears a mesh suit to help her new skin bind, and remains imprisoned in a near-empty room while it does.

Then a thief in a tiger costume shows up at the door, which may come as a point of bewilderment to viewers, as it signals a quick shift in tone that makes “Skin”’s two hours feel like back-to-back chapters rather than a cohesive whole.

But grant Almodóvar your patience, and trust that he has a point. He does, and it’s going to sting — in a good way, for the open-minded.

Taking more than a few visual cues from the 1960 French classic “Eyes Without a Face” and Fritz Lang’s “Dr. Mabuse” series, Almodóvar uses the constructs of a thriller to investigate man’s animal instincts — the urges that explode into violence when left unchecked (“I’ve got insanity in my entrails!”) — and our desire to be someone we are not.

Through a twisting plot of twisted logic and gross anatomy, the director employs a sharp, clinical touch with his camera, capturing settings both high-tech sterile and old-Spain ornate.

A purposely stoic Banderas relies more on facial muscles than his charmed face to inhabit the surgeon whose life is comprised of pain, which he takes out on Vera. “The Skin I Live In,” like Dr. Ledgard’s subject, is not without its flaws, but good enough to pass and easy on the eyes.