The benefit comes at a time when CityRep, like so many arts organizations during the recession, has had a shortfall in financial support.
"We're very grateful for all the support we do get, but it's very hard to get an actor to work for a tenth of what he did last year," said Don Jordan, CityRep's artistic director, noting events like this fundraiser help CityRep continue to run.
In addition to his work on "Star Trek: Voyager," Picardo also appeared in "The Wonder Years," for which he was nominated for an Emmy.
The benefit performances will be largely informal, with Picardo catering in large part to the desires of the audience.
"I'll be regaling people with anecdotes about 'Star Trek' in particular and anything else they want to talk about," he said. "I might be showing some video clips and singing. Whatever the audience wants, I'll be happy to oblige, as long as they make their financial contribution!"
Jordan said that because of the intimate size of the CitySpace Theater, audiences are going to have a truly personal experience with Picardo.
"As opposed to a convention hall with 2,500 seats, the furthest seat from the stage is only about 8 feet away. That's about as intimate as you can be without being in his dressing room," Jordan said.
Because of a patron donation, all tickets to the fundraiser — which were originally going for up to $100 — are "pay what you can."
CityRep also will raffle $10 tickets for a chance to have lunch with Picardo on Sunday at Oklahoma City Museum of Art Cafe.